Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | MMP10 | P09238 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.30 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.30 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24325763 | 1.00 | MMP3 (0.32) | MMP3MMP7MMP10MMP12P2RX3 | |
| SCHEMBL24326684 | 0.87 | P2RX3 (0.33) | MMP3MMP7MMP10MMP12P2RX3 | |
| SCHEMBL29571934 | 0.87 | TGFBR1 (0.38) | — | |
| SCHEMBL29570662 | 0.87 | TGFBR1 (0.38) | — | |
| SCHEMBL29571030 | 0.87 | TGFBR1 (0.38) | — | |
| SCHEMBL24325778 | 0.87 | TGFBR1 (0.38) | — | |
| SCHEMBL24326676 | 0.87 | TGFBR1 (0.38) | — | |
| SCHEMBL24325766 | 0.87 | TGFBR1 (0.38) | — | |
| SCHEMBL29570877 | 0.87 | TGFBR1 (0.38) | — | |
| SCHEMBL29570625 | 0.87 | TGFBR1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |