Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24326988 | 0.83 | MEN1 (0.47) | MAPTSMN1; SMN2POLBGLAMEN1 | |
| SCHEMBL24326986 | 0.81 | NPBWR1 (0.40) | MAPTPOLBGLAMEN1KMT2A | |
| SCHEMBL26777768 | 0.80 | MAPT (0.36) | MAPTSMN1; SMN2POLBGLAMEN1 | |
| SCHEMBL24327000 | 0.79 | TP53 (0.40) | SMN1; SMN2POLBGLAMEN1KMT2A | |
| SCHEMBL30858609 | 0.76 | GAA (0.39) | MAPTPOLBMEN1KMT2A | |
| SCHEMBL14591313 | 0.73 | ALOX12 (0.47) | MAPTPOLBGLAMEN1KMT2A | |
| SCHEMBL2883166 | 0.73 | GAA (0.41) | MAPTSMN1; SMN2POLBGLAMEN1 | |
| SCHEMBL26777757 | 0.69 | MEN1 (0.39) | MAPTSMN1; SMN2POLBGLAMEN1 | |
| SCHEMBL24327448 | 0.68 | MEN1 (0.36) | MAPTSMN1; SMN2POLBGLAMEN1 | |
| SCHEMBL24326976 | 0.66 | HTR2C (0.38) | MAPTPOLBGLAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |