Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24326976 | 0.86 | HTR2C (0.38) | MEN1KMT2AHTTALDH1A1LMNA | |
| SCHEMBL24326968 | 0.81 | HTR2C (0.35) | MEN1KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL24326971 | 0.81 | NPSR1 (0.37) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL24351819 | 0.80 | HTR2A (0.39) | MEN1KMT2ALMNAMAPTHTR2C | |
| SCHEMBL24351831 | 0.79 | HTR2C (0.40) | MEN1KMT2ALMNAMAPTPOLB | |
| SCHEMBL24326972 | 0.78 | HTR2C (0.40) | MEN1KMT2AHTTALDH1A1TSHR | |
| SCHEMBL24351816 | 0.78 | KDM4E (0.34) | MEN1KMT2ALMNAPOLBHTR2C | |
| SCHEMBL24351832 | 0.77 | HTR6 (0.41) | MEN1KMT2AHTTALDH1A1MAPT | |
| SCHEMBL14591313 | 0.70 | ALOX12 (0.47) | MEN1KMT2AHTTALDH1A1LMNA | |
| SCHEMBL24326969 | 0.68 | MAPT (0.38) | MEN1KMT2AMAPTPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022068849-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF EGFR AND RELATED METHODS OF USE | BEIGENE, LTD. (KY) | 2022-04-07 | — | — | WO | disclosed |
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |