Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.34 |
| ▸ | LGMN | Q99538 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22942152 | 0.88 | CARM1 (0.38) | CARM1PRMT6PRMT8KDM4EALDH1A1 | |
| SCHEMBL24204819 | 0.82 | EPHX1 (0.39) | KDM4EALDH1A1SSTR5LGMNGAA | |
| SCHEMBL23153933 | 0.77 | HTR4 (0.38) | CARM1PRMT6PRMT8KDM4EALDH1A1 | |
| SCHEMBL23759702 | 0.76 | CARM1 (0.38) | CARM1PRMT6PRMT8DRD2ADRA2B | |
| SCHEMBL25011531 | 0.75 | GAA (0.42) | GAASMN1; SMN2 | |
| SCHEMBL310526 | 0.74 | EGFR (0.39) | KDM4EALDH1A1LGMNMAPTMEN1 | |
| SCHEMBL24993039 | 0.73 | CARM1 (0.39) | CARM1PRMT6PRMT8 | |
| SCHEMBL24107900 | 0.73 | NTSR1 (0.33) | CARM1PRMT6PRMT8KDM4EALDH1A1 | |
| SCHEMBL26418294 | 0.72 | CARM1 (0.44) | CARM1PRMT6PRMT8ALDH1A1GAA | |
| SCHEMBL23759658 | 0.71 | CARM1 (0.40) | CARM1PRMT6PRMT8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |