SCHEMBL24327375 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	JAK2	O60674	6/20	0.40

▸	JAK1	P23458	6/20	0.40

▸	TYK2	P29597	6/20	0.40

▸	JAK3	P52333	6/20	0.40

▸	AHR	P35869	1/20	0.36

▸	SYK	P43405	1/20	0.36

▸	EIF2AK4	Q9P2K8	1/20	0.36

▸	TTK	P33981	1/20	0.35

▸	FGFR3	P22607	1/20	0.34

▸	KDR	P35968	1/20	0.34

▸	IDH1	O75874	1/20	0.34

▸	MAPK1	P28482	5/20	0.33

▸	RET	P07949	1/20	0.33

▸	PIK3CA	P42336	2/20	0.33

▸	MTOR	P42345	2/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL29601453	0.90	JAK2 (0.44)	JAK2JAK1TYK2JAK3AHR
SCHEMBL24327328	0.90	JAK2 (0.44)	JAK2JAK1TYK2JAK3AHR
SCHEMBL24327333	0.90	JAK2 (0.44)	JAK2JAK1TYK2JAK3AHR
SCHEMBL24328767	0.81	JAK2 (0.43)	JAK2JAK1TYK2JAK3TTK
SCHEMBL24327390	0.81	JAK2 (0.43)	JAK2JAK1TYK2JAK3SYK
SCHEMBL24327891	0.80	TRPV3 (0.41)	JAK2JAK1TYK2JAK3SYK
SCHEMBL24327373	0.80	FGFR3 (0.44)	JAK2JAK1TYK2JAK3FGFR3
SCHEMBL24327764	0.79	FGFR3 (0.41)	JAK2JAK1TYK2JAK3FGFR3
SCHEMBL29601173	0.79	FGFR3 (0.41)	JAK2JAK1TYK2JAK3FGFR3
SCHEMBL29601470	0.79	JAK2 (0.40)	JAK2JAK1TYK2JAK3AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022078356-A1	HETEROAROMATIC AHR INHIBITOR	山东轩竹医药科技有限公司	2022-04-21	—	—	WO	disclosed