Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.43 |
| ▸ | JAK3 | P52333 | 8/20 | 0.43 |
| ▸ | JAK1 | P23458 | 7/20 | 0.43 |
| ▸ | TYK2 | P29597 | 7/20 | 0.43 |
| ▸ | TRPV3 | Q8NET8 | 5/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327390 | 0.89 | JAK2 (0.43) | JAK2JAK3JAK1TYK2TTK | |
| SCHEMBL24327328 | 0.89 | JAK2 (0.44) | JAK2JAK3JAK1TYK2TTK | |
| SCHEMBL29601453 | 0.89 | JAK2 (0.44) | JAK2JAK3JAK1TYK2TTK | |
| SCHEMBL24327333 | 0.89 | JAK2 (0.44) | JAK2JAK3JAK1TYK2TTK | |
| SCHEMBL24327891 | 0.88 | TRPV3 (0.41) | JAK2JAK3JAK1TYK2TRPV3 | |
| SCHEMBL24328770 | 0.86 | EPHB4 (0.41) | JAK2JAK3JAK1TYK2EPHB4 | |
| SCHEMBL24327771 | 0.85 | TEK (0.43) | JAK2JAK3JAK1TYK2TRPV3 | |
| SCHEMBL24539587 | 0.83 | JAK2 (0.43) | JAK2JAK3JAK1TYK2TRPV3 | |
| SCHEMBL24539590 | 0.83 | JAK2 (0.42) | JAK2JAK3JAK1TYK2TRPV3 | |
| SCHEMBL24539461 | 0.83 | JAK2 (0.42) | JAK2JAK3JAK1TYK2TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |