Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327324 | 0.89 | FGFR3 (0.50) | MAPK1KDRCSF1RFGFR3FGFR1 | |
| SCHEMBL24328691 | 0.85 | EPHB4 (0.46) | MAPK1EPHB4TEKCSF1RFGFR3 | |
| SCHEMBL29498914 | 0.85 | EPHB4 (0.46) | MAPK1EPHB4TEKCSF1RFGFR3 | |
| SCHEMBL24539466 | 0.84 | MAPK1 (0.41) | LRRK2MAPK1KDREPHB4TEK | |
| SCHEMBL24327855 | 0.83 | LRRK2 (0.58) | LRRK2MAPK1KDREPHB4TEK | |
| SCHEMBL29498936 | 0.80 | FGFR3 (0.48) | LRRK2MAPK1KDREPHB4TEK | |
| SCHEMBL24327388 | 0.80 | FGFR3 (0.48) | LRRK2MAPK1KDREPHB4TEK | |
| SCHEMBL28724019 | 0.77 | FGFR3 (0.51) | LRRK2MAPK1KDRRAB9ACSF1R | |
| SCHEMBL29601464 | 0.72 | KDR (0.44) | MAPK1KDRCSF1RFGFR3CHEK1 | |
| SCHEMBL24327260 | 0.72 | LRRK2 (0.45) | LRRK2KDREPHB4TEKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114369097-B | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |