Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29498914 | 1.00 | EPHB4 (0.46) | EPHB4TEKFGFR2FGFR3NPBWR1 | |
| SCHEMBL24327401 | 0.85 | LRRK2 (0.45) | EPHB4TEKFGFR2FGFR3MAPK1 | |
| SCHEMBL24327324 | 0.84 | FGFR3 (0.50) | FGFR2FGFR3KCNH2MAPK1CDK2 | |
| SCHEMBL24327773 | 0.84 | KCNH2 (0.55) | EPHB4TEKFGFR2FGFR3NPBWR1 | |
| SCHEMBL24328692 | 0.81 | EPHB4 (0.40) | EPHB4TEKFGFR2FGFR3NPBWR1 | |
| SCHEMBL24327987 | 0.77 | LMNA (0.41) | EPHB4TEKKCNH2CDK2CCNK | |
| SCHEMBL24327883 | 0.74 | TEK (0.46) | EPHB4TEKFGFR2FGFR3NPBWR1 | |
| SCHEMBL28724019 | 0.73 | FGFR3 (0.51) | FGFR2FGFR3KCNH2MAPK1CDK2 | |
| SCHEMBL28761425 | 0.72 | CHEK1 (0.45) | EPHB4TEKFGFR2FGFR3NPBWR1 | |
| SCHEMBL25460302 | 0.71 | TEK (0.52) | EPHB4TEKFGFR3NPBWR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114369097-B | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |