Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.41 |
| ▸ | JAK3 | P52333 | 18/20 | 0.41 |
| ▸ | TYK2 | P29597 | 17/20 | 0.41 |
| ▸ | JAK2 | O60674 | 15/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327345 | 0.90 | JAK1 (0.40) | JAK1JAK3TYK2JAK2AXL | |
| SCHEMBL29601453 | 0.88 | JAK2 (0.44) | JAK1JAK3TYK2JAK2AHR | |
| SCHEMBL24327328 | 0.88 | JAK2 (0.44) | JAK1JAK3TYK2JAK2AHR | |
| SCHEMBL24327333 | 0.88 | JAK2 (0.44) | JAK1JAK3TYK2JAK2AHR | |
| SCHEMBL29498928 | 0.83 | JAK1 (0.35) | JAK1JAK3TYK2JAK2AXL | |
| SCHEMBL24327375 | 0.79 | JAK2 (0.40) | JAK1JAK3TYK2JAK2AHR | |
| SCHEMBL24327408 | 0.79 | AHR (0.36) | JAK1JAK3TYK2JAK2AHR | |
| SCHEMBL29601470 | 0.78 | JAK2 (0.40) | JAK1JAK3TYK2JAK2AHR | |
| SCHEMBL24328767 | 0.78 | JAK2 (0.43) | JAK1JAK3TYK2JAK2 | |
| SCHEMBL24327390 | 0.78 | JAK2 (0.43) | JAK1JAK3TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |