SCHEMBL24327345 — predicted protein targets

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	JAK1	P23458	19/20	0.40

▸	JAK3	P52333	19/20	0.40

▸	TYK2	P29597	18/20	0.40

▸	JAK2	O60674	16/20	0.40

▸	AXL	P30530	1/20	0.36

▸	FLT3	P36888	1/20	0.36

▸	TYRO3	Q06418	1/20	0.36

▸	MERTK	Q12866	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL24327409	0.90	JAK1 (0.41)	JAK1JAK3TYK2JAK2AXL
SCHEMBL24327390	0.89	JAK2 (0.43)	JAK1JAK3TYK2JAK2
SCHEMBL29498931	0.83	JAK1 (0.34)	JAK1JAK3TYK2JAK2AXL
SCHEMBL24327882	0.83	JAK1 (0.36)	JAK1JAK3TYK2JAK2
SCHEMBL24327786	0.82	JAK1 (0.39)	JAK1JAK3TYK2JAK2
SCHEMBL24328767	0.78	JAK2 (0.43)	JAK1JAK3TYK2JAK2
SCHEMBL24327328	0.78	JAK2 (0.44)	JAK1JAK3TYK2JAK2
SCHEMBL24327333	0.78	JAK2 (0.44)	JAK1JAK3TYK2JAK2
SCHEMBL29601453	0.78	JAK2 (0.44)	JAK1JAK3TYK2JAK2
SCHEMBL24328717	0.77	JAK1 (0.37)	JAK1JAK3TYK2JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022078356-A1	HETEROAROMATIC AHR INHIBITOR	山东轩竹医药科技有限公司	2022-04-21	—	—	WO	disclosed
CN-114369097-A	Heteroaromatic AhR inhibitors	山东轩竹医药科技有限公司	2022-04-19	—	—	CN	disclosed