Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24328350 | 0.82 | PRKCZ (0.38) | GAAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL29661308 | 0.82 | PRKCZ (0.38) | GAAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL24328515 | 0.82 | PRKCZ (0.40) | GAAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL24327497 | 0.81 | GAA (0.36) | GAAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL29661326 | 0.78 | PARP1 (0.40) | GAAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL24328563 | 0.78 | PARP1 (0.40) | GAAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL24327352 | 0.76 | POLB (0.41) | GAAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL24327498 | 0.74 | TIPARP (0.34) | GAAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL29661397 | 0.74 | TIPARP (0.34) | GAAMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL15586058 | 0.74 | ALDH1A1 (0.50) | GAAMEN1KMT2AUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |