Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24328518 | 0.83 | ALDH1A1 (0.40) | POLBGAAMEN1USP2KMT2A | |
| SCHEMBL26655419 | 0.80 | GAA (0.39) | POLBGAAMEN1USP2KMT2A | |
| SCHEMBL30206323 | 0.78 | ALDH1A1 (0.47) | POLBGAAKDM4EMAPTHTT | |
| SCHEMBL24107836 | 0.78 | ALDH1A1 (0.47) | POLBGAAKDM4EMAPTHTT | |
| SCHEMBL24328564 | 0.76 | GAA (0.43) | POLBGAAMEN1USP2KMT2A | |
| SCHEMBL28313862 | 0.76 | ALDH1A1 (0.51) | POLBGAAMEN1USP2KMT2A | |
| SCHEMBL29661314 | 0.76 | KDM4E (0.38) | POLBGAAKDM4EMAPTHTT | |
| SCHEMBL24327660 | 0.76 | KDM4E (0.38) | POLBGAAKDM4EMAPTHTT | |
| SCHEMBL26407202 | 0.76 | ADRA2C (0.70) | POLBGAAMEN1USP2KMT2A | |
| SCHEMBL22587670 | 0.74 | FGFR3 (0.39) | POLBGAAKDM4EMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |