Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | SGK1 | O00141 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24351534 | 0.84 | NUDT1 (0.35) | RPS6KB1HTR2C | |
| SCHEMBL24327036 | 0.72 | CDK1 (0.39) | — | |
| SCHEMBL24327019 | 0.71 | ALDH1A1 (0.33) | LMNAMAPTMAPK1 | |
| SCHEMBL3984786 | 0.62 | PIK3CA (0.49) | RPS6KB1LMNAMAPTBTKSGK1 | |
| SCHEMBL24328339 | 0.60 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL55757 | 0.60 | MTOR (0.40) | SGK1PDE2A | |
| SCHEMBL560806 | 0.58 | RET (0.52) | MAPTHTTBTKHTR2AHTR2C | |
| SCHEMBL24672317 | 0.58 | AKT2 (0.38) | BTKSGK1PDE2A | |
| SCHEMBL24327450 | 0.58 | ABL1 (0.31) | — | |
| SCHEMBL53863 | 0.58 | PLK4 (0.47) | LMNABTKPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |