Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 5/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.41 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327347 | 0.90 | KDR (0.53) | FGFR3KDRCNR1CNR2KCNH2 | |
| SCHEMBL29498933 | 0.90 | KDR (0.53) | FGFR3KDRCNR1CNR2KCNH2 | |
| SCHEMBL24327370 | 0.87 | FGFR3 (0.51) | FGFR3KDRCNR1CNR2KCNH2 | |
| SCHEMBL24327350 | 0.84 | FGFR3 (0.56) | FGFR3KDRCNR1CNR2KCNH2 | |
| SCHEMBL29498949 | 0.84 | FGFR3 (0.56) | FGFR3KDRCNR1CNR2KCNH2 | |
| SCHEMBL24327827 | 0.82 | FGFR3 (0.53) | FGFR3KDRFGFR1FGFR2CSF1R | |
| SCHEMBL24328711 | 0.80 | CHEK1 (0.52) | FGFR3KDRCNR1CNR2CHEK1 | |
| SCHEMBL24328681 | 0.80 | FGFR3 (0.49) | FGFR3KDRCNR1CNR2KCNH2 | |
| SCHEMBL24328682 | 0.80 | FGFR3 (0.46) | FGFR3KDRCHEK1FGFR1FGFR2 | |
| SCHEMBL30519232 | 0.80 | FGFR3 (0.46) | FGFR3KDRCHEK1FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114369097-B | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |