Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 6/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.36 |
| ▸ | TEK | Q02763 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 7/20 | 0.33 |
| ▸ | JAK1 | P23458 | 7/20 | 0.33 |
| ▸ | TYK2 | P29597 | 7/20 | 0.33 |
| ▸ | JAK3 | P52333 | 6/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24328751 | 1.00 | IRAK1 (0.43) | IRAK1KDREPHB4TEKJAK2 | |
| SCHEMBL24328760 | 1.00 | IRAK1 (0.43) | IRAK1KDREPHB4TEKJAK2 | |
| SCHEMBL24328753 | 0.92 | IRAK1 (0.42) | IRAK1KDREPHB4TEKJAK2 | |
| SCHEMBL24327322 | 0.82 | IRAK1 (0.43) | IRAK1KDREPHB4TEKJAK2 | |
| SCHEMBL29498943 | 0.81 | EP300 (0.31) | KDREPHB4TEKJAK2JAK1 | |
| SCHEMBL24327879 | 0.75 | TEK (0.45) | KDREPHB4TEKJAK2JAK1 | |
| SCHEMBL24327878 | 0.74 | EPHB4 (0.42) | EPHB4TEKJAK2JAK1TYK2 | |
| SCHEMBL24327407 | 0.74 | IRAK1 (0.42) | IRAK1KDRJAK2JAK1TYK2 | |
| SCHEMBL24327327 | 0.71 | TEK (0.47) | KDREPHB4TEKJAK2JAK1 | |
| SCHEMBL24327329 | 0.71 | EPHB4 (0.42) | IRAK1EPHB4TEKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |