Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 3/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.33 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | EP300 | Q09472 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24328751 | 0.92 | IRAK1 (0.43) | IRAK1CHEK1EPHB4TEKFGFR1 | |
| SCHEMBL24328734 | 0.92 | IRAK1 (0.43) | IRAK1CHEK1EPHB4TEKFGFR1 | |
| SCHEMBL24328760 | 0.92 | IRAK1 (0.43) | IRAK1CHEK1EPHB4TEKFGFR1 | |
| SCHEMBL24327407 | 0.82 | IRAK1 (0.42) | IRAK1CLK1GAAFGFR1FGFR2 | |
| SCHEMBL24327399 | 0.80 | AHR (0.41) | CHEK1MAPKAPK2CLK1FGFR3KDR | |
| SCHEMBL24327363 | 0.79 | TTK (0.39) | IRAK1CHEK1MAPKAPK2CLK1EP300 | |
| SCHEMBL24327880 | 0.76 | CNR1 (0.40) | CHEK1MAPKAPK2CLK1FGFR3KDR | |
| SCHEMBL24327876 | 0.76 | CNR1 (0.38) | CHEK1MAPKAPK2CLK1EP300CNR1 | |
| SCHEMBL24327879 | 0.74 | TEK (0.45) | CHEK1EPHB4TEKKDRJAK2 | |
| SCHEMBL24327322 | 0.74 | IRAK1 (0.43) | IRAK1EPHB4TEKFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |