Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.41 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 4/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.41 |
| ▸ | MERTK | Q12866 | 3/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24328762 | 0.87 | TRPV3 (0.40) | EPHB4TEKAXLMERTKSCD | |
| SCHEMBL24327879 | 0.87 | TEK (0.45) | EPHB4TEKCCNKCCNA2CDK2 | |
| SCHEMBL24327327 | 0.81 | TEK (0.47) | EPHB4TEKSCDCHEK1JAK2 | |
| SCHEMBL24327878 | 0.80 | EPHB4 (0.42) | EPHB4TEKSCDJAK2JAK1 | |
| SCHEMBL24328759 | 0.72 | TEK (0.41) | EPHB4TEKSCDJAK2JAK1 | |
| SCHEMBL24328760 | 0.71 | IRAK1 (0.43) | EPHB4TEKCHEK1JAK2JAK1 | |
| SCHEMBL24328734 | 0.71 | IRAK1 (0.43) | EPHB4TEKCHEK1JAK2JAK1 | |
| SCHEMBL24328751 | 0.71 | IRAK1 (0.43) | EPHB4TEKCHEK1JAK2JAK1 | |
| SCHEMBL24327773 | 0.68 | KCNH2 (0.55) | EPHB4TEKNPBWR1 | |
| SCHEMBL24328691 | 0.68 | EPHB4 (0.46) | EPHB4TEKCCNKCCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |