Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 4/20 | 0.38 |
| ▸ | TYK2 | P29597 | 4/20 | 0.38 |
| ▸ | JAK3 | P52333 | 4/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 7/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24328754 | 0.88 | JAK2 (0.39) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL24327878 | 0.81 | EPHB4 (0.42) | TEKEPHB4JAK2JAK1TYK2 | |
| SCHEMBL24327877 | 0.79 | JAK2 (0.36) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL24327327 | 0.79 | TEK (0.47) | TEKEPHB4JAK2JAK1TYK2 | |
| SCHEMBL24327881 | 0.77 | JAK1 (0.37) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL24539587 | 0.76 | JAK2 (0.43) | TEKEPHB4JAK2JAK1TYK2 | |
| SCHEMBL24327879 | 0.76 | TEK (0.45) | TEKEPHB4JAK2JAK1TYK2 | |
| SCHEMBL24328756 | 0.75 | CNR1 (0.39) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL24327384 | 0.74 | DPP4 (0.32) | CYP11B2MAPK1 | |
| SCHEMBL24327848 | 0.73 | JAK2 (0.43) | JAK2JAK1TYK2JAK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |