Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.43 |
| ▸ | JAK1 | P23458 | 12/20 | 0.43 |
| ▸ | TYK2 | P29597 | 12/20 | 0.43 |
| ▸ | JAK3 | P52333 | 11/20 | 0.43 |
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24539406 | 0.88 | JAK2 (0.45) | JAK2JAK1TYK2JAK3F2RL3 | |
| SCHEMBL24539407 | 0.88 | JAK2 (0.45) | JAK2JAK1TYK2JAK3F2RL3 | |
| SCHEMBL24328767 | 0.83 | JAK2 (0.43) | JAK2JAK1TYK2JAK3TEK | |
| SCHEMBL24539590 | 0.83 | JAK2 (0.42) | JAK2JAK1TYK2JAK3TEK | |
| SCHEMBL24539461 | 0.83 | JAK2 (0.42) | JAK2JAK1TYK2JAK3TEK | |
| SCHEMBL24327405 | 0.82 | JAK2 (0.42) | JAK2JAK1TYK2JAK3TEK | |
| SCHEMBL24327771 | 0.80 | TEK (0.43) | JAK2JAK1TYK2JAK3TEK | |
| SCHEMBL24328770 | 0.79 | EPHB4 (0.41) | JAK2JAK1TYK2JAK3TEK | |
| SCHEMBL24328759 | 0.76 | TEK (0.41) | JAK2JAK1TYK2JAK3TEK | |
| SCHEMBL24539484 | 0.73 | JAK2 (0.41) | JAK2JAK1TYK2JAK3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022127753-A1 | FUSED RING AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-06-23 | — | — | WO | disclosed |