Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATG4B | Q9Y4P1 | 6/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7706723 | 0.76 | TYMS (0.49) | — | |
| SCHEMBL9094213 | 0.76 | CHRM1 (0.54) | CES1MEN1KMT2ACHRM1DRD2 | |
| SCHEMBL27006381 | 0.74 | DRD2 (0.35) | CES1KMT2ADRD2PARP1 | |
| SCHEMBL29532654 | 0.74 | DRD2 (0.35) | CES1KMT2ADRD2PARP1 | |
| SCHEMBL27453740 | 0.74 | ATG4B (0.52) | ATG4BMEN1PKMKMT2ASMN1; SMN2 | |
| SCHEMBL7709769 | 0.73 | ERCC1 (0.53) | MEN1KMT2A | |
| SCHEMBL31443843 | 0.71 | MAOA (0.54) | CES1SMN1; SMN2CHRM1DRD2DRD4 | |
| Trifluoromethanesulfonic Acid SCHEMBL18319693 | 0.71 | KMT2A (0.49) | ATG4BMEN1PKMKMT2ASMN1; SMN2 | |
| SCHEMBL1096873 | 0.71 | MEN1 (0.51) | ATG4BMEN1PKMKMT2ASMN1; SMN2 | |
| SCHEMBL31682515 | 0.70 | ADORA2A (0.33) | CHRM1DRD2DRD4DRD3CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081928-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |