Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.35 |
| ▸ | GLRB | P48167 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.34 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12162722 | 0.83 | GLRA3 (0.44) | SMN1; SMN2TP53CYP2C9CYP2C19HIF1A | |
| SCHEMBL16117701 | 0.82 | L3MBTL1 (0.42) | SMN1; SMN2TP53CYP2C9CYP2C19HIF1A | |
| SCHEMBL13222559 | 0.79 | KDM4E (0.43) | SMN1; SMN2TP53CYP2C9CYP2C19HIF1A | |
| SCHEMBL12162731 | 0.79 | GAA (0.47) | SMN1; SMN2NR1H4ALDH1A1KDM4EMAPT | |
| SCHEMBL24910469 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2TP53CYP2C9CYP2C19HIF1A | |
| SCHEMBL25950790 | 0.73 | NR1H4 (0.40) | SMN1; SMN2TP53CYP2C9CYP2C19HIF1A | |
| SCHEMBL12251356 | 0.71 | NR1H4 (0.35) | SMN1; SMN2TP53CYP2C9CYP2C19HIF1A | |
| SCHEMBL16117676 | 0.69 | L3MBTL1 (0.42) | SMN1; SMN2TP53CYP2C9CYP2C19HIF1A | |
| SCHEMBL12733032 | 0.69 | SMN1; SMN2 (0.42) | SMN1; SMN2TP53CYP2C9CYP2C19HIF1A | |
| SCHEMBL31497679 | 0.69 | SMN1; SMN2 (0.45) | SMN1; SMN2TP53CYP2C9CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119385-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119385-A1 | BICYCLIC COMPOUNDS | SLC10A1, PKD1, CYP11B2 | SMN1; SMN2 611/4885TP53 2350/4885CYP2C9 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.