Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26841565 | 0.87 | GLA (0.51) | ALDH1A1MAPK1L3MBTL1GLAMGLL | |
| SCHEMBL335071 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1MGLL | |
| SCHEMBL24298393 | 0.77 | ALDH1A1 (0.44) | ALDH1A1MAPK1L3MBTL1NOTUMGLA | |
| SCHEMBL24298386 | 0.77 | ALDH1A1 (0.44) | ALDH1A1MAPK1L3MBTL1NOTUMGLA | |
| SCHEMBL25251528 | 0.75 | ALDH1A1 (0.42) | ALDH1A1MAPK1L3MBTL1NOTUMGLA | |
| SCHEMBL13183363 | 0.75 | ALDH1A1 (0.42) | ALDH1A1MAPK1L3MBTL1NOTUMGLA | |
| SCHEMBL10759726 | 0.74 | GLA (0.46) | ALDH1A1MAPK1L3MBTL1NOTUMGLA | |
| SCHEMBL18744471 | 0.74 | ALDH1A1 (0.44) | ALDH1A1MAPK1L3MBTL1GLAKMT2A | |
| SCHEMBL335391 | 0.74 | MGLL (0.53) | ALDH1A1MAPK1L3MBTL1MGLLEPHX2 | |
| SCHEMBL29307410 | 0.74 | ALDH1A1 (0.50) | ALDH1A1MAPK1L3MBTL1NOTUMGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076620-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |