Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.34 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | RRM1 | P23921 | 1/20 | 0.33 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | IDH1 | O75874 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29469637 | 0.83 | POLB (0.37) | LMNATP53MAPTALDH1A1POLB | |
| SCHEMBL24333964 | 0.81 | HTR6 (0.33) | LMNATP53MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL24333639 | 0.80 | TSHR (0.43) | LMNATP53MAPTALDH1A1TSHR | |
| SCHEMBL24333956 | 0.79 | — | — | |
| SCHEMBL24334394 | 0.79 | PGAM1 (0.33) | LMNAMAPTALDH1A1TSHRPOLB | |
| SCHEMBL24333723 | 0.78 | KMT2A (0.34) | TSHRSMN1; SMN2POLBL3MBTL1HPGD | |
| SCHEMBL24333402 | 0.77 | ALDH1A1 (0.45) | LMNATP53MAPTALDH1A1TSHR | |
| SCHEMBL24333670 | 0.77 | CCR8 (0.33) | LMNATP53MAPTALDH1A1TSHR | |
| SCHEMBL24334438 | 0.77 | SLC22A12 (0.36) | MAPTCHRM1ALDH1A1NPSR1KMT2A | |
| SCHEMBL24333658 | 0.77 | ALDH1A1 (0.35) | MAPTALDH1A1SMN1; SMN2HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |