Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29469638 | 1.00 | MMP2 (0.38) | MMP2PTGER1MRGPRX4PSMD14USP2 | |
| SCHEMBL24333633 | 0.93 | PTGER1 (0.39) | MMP2PTGER1MRGPRX4LRRK2ABCB1 | |
| SCHEMBL29469636 | 0.93 | PTGER1 (0.39) | MMP2PTGER1MRGPRX4LRRK2ABCB1 | |
| SCHEMBL24333765 | 0.90 | USP2 (0.36) | USP2NPC1HPGDHTTDRD2 | |
| SCHEMBL29469721 | 0.89 | SCN9A (0.36) | — | |
| SCHEMBL24333693 | 0.89 | SCN9A (0.36) | — | |
| SCHEMBL29469621 | 0.88 | PTGDR (0.36) | MMP2TP53NPC1HTT | |
| SCHEMBL24333945 | 0.87 | PTGER1 (0.36) | MMP2PTGER1LRRK2KDM1AMAOB | |
| SCHEMBL29469650 | 0.87 | PTGER1 (0.36) | MMP2PTGER1LRRK2KDM1AMAOB | |
| SCHEMBL24333958 | 0.86 | ALDH1A1 (0.33) | MMP2PSMD14USP2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |