Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | SCN1A | P35498 | 3/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24333945 | 1.00 | PTGER1 (0.36) | PTGER1SCN9AMMP2ACHESCN1A | |
| SCHEMBL24333633 | 0.89 | PTGER1 (0.39) | PTGER1MMP2LRRK2 | |
| SCHEMBL29469636 | 0.89 | PTGER1 (0.39) | PTGER1MMP2LRRK2 | |
| SCHEMBL29469915 | 0.89 | SCN9A (0.34) | SCN9AMMP2ACHEPDE4APDE4B | |
| SCHEMBL24333336 | 0.89 | SCN9A (0.34) | SCN9AMMP2ACHEPDE4APDE4B | |
| SCHEMBL24333397 | 0.87 | MMP2 (0.38) | PTGER1MMP2KDM1ALRRK2MAOB | |
| SCHEMBL29469638 | 0.87 | MMP2 (0.38) | PTGER1MMP2KDM1ALRRK2MAOB | |
| SCHEMBL24333946 | 0.83 | LRRK2 (0.34) | MMP2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24334278 | 0.83 | HRH1 (0.35) | SCN9ASCN1ASCN8AKCNH2MCHR1 | |
| SCHEMBL29469716 | 0.83 | HRH1 (0.35) | SCN9ASCN1ASCN8AKCNH2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | claimed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | claimed |
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |