SCHEMBL24337010

SCHEMBL24337010

CSNc1ccccc1-c1ccc(N2CCCC2=O)c(F)c1F

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.39
NPC1 O15118 1/20 0.39
FPR2 P25090 10/20 0.39
ALOX5AP P20292 1/20 0.38
FEN1 P39748 1/20 0.38
GFER P55789 1/20 0.38
FPR1 P21462 9/20 0.37
POLB P06746 1/20 0.37
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
HPGD P15428 1/20 0.36
KMT2A Q03164 1/20 0.36
PDK2 Q15119 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TSHR P16473 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21319429 0.83 FPR2 (0.54) FPR2ALOX5APFEN1FPR1MEN1
SCHEMBL24093609 0.82 NPC1 (0.44) RAB9ANPC1FPR2ALOX5APFEN1
SCHEMBL24093577 0.77 ALOX5AP (0.40) FPR2ALOX5APFEN1GFERFPR1
SCHEMBL24093571 0.76 RAB9A (0.53) RAB9ANPC1GFERMEN1LMNA
SCHEMBL24336656 0.76 FPR2 (0.48) FPR2FPR1
SCHEMBL24336806 0.76 FPR2 (0.48) FPR2FPR1
SCHEMBL24093601 0.75 ALOX5AP (0.39) FPR2ALOX5APFEN1GFERFPR1
SCHEMBL24093528 0.70 FPR2 (0.53) FPR2ALOX5APFEN1FPR1
SCHEMBL23168572 0.70 HSD17B10 (0.42) LMNAHPGDL3MBTL1
SCHEMBL21341136 0.67 HSD17B10 (0.44) RAB9ANPC1ALOX5APFEN1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3981767-A1 PHENYLPYRROLIDINONE FORMYL PEPTIDE 2 RECEPTOR AGONISTS Bristol-Myers Squibb Company (US) 2022-04-13 EP disclosed