Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.30 |
| ▸ | JAK1 | P23458 | 2/20 | 0.30 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1936514 | 0.83 | ALDH1A1 (0.45) | ALDH1A1TRPM8 | |
| SCHEMBL2469800 | 0.82 | CSNK1D (0.37) | ALDH1A1CNR2CNR1CSNK1DCSNK1E | |
| SCHEMBL2464901 | 0.82 | CYP2C8 (0.43) | CNR2CNR1 | |
| SCHEMBL2468592 | 0.81 | GRM4 (0.36) | CNR2CNR1 | |
| SCHEMBL2465370 | 0.79 | CYP2C8 (0.40) | CNR2CNR1CSNK1DCSNK1E | |
| SCHEMBL2432013 | 0.75 | CSF1R (0.31) | CNR2ABHD6 | |
| SCHEMBL2470386 | 0.74 | CYP2C8 (0.44) | CNR2CNR1CSNK1DCSNK1EABHD6 | |
| SCHEMBL2467631 | 0.74 | NPC1 (0.38) | CNR2CNR1CSNK1DCSNK1EABHD6 | |
| SCHEMBL2468380 | 0.74 | CSNK1D (0.37) | CNR2CNR1CSNK1DCSNK1EABHD6 | |
| SCHEMBL2467958 | 0.72 | CNR1 (0.38) | CNR2CNR1CSNK1DCSNK1EABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545050-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | Bristol-Myers Squibb Company (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112186-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-09-15 | — | — | WO | disclosed |