Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.62 |
| ▸ | FLT1 | P17948 | 4/20 | 0.62 |
| ▸ | FLT4 | P35916 | 4/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434355 | 0.90 | KDR (0.76) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2431862 | 0.88 | KDR (0.59) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2431354 | 0.88 | KDR (0.65) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2436698 | 0.85 | KDR (0.78) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2438876 | 0.83 | KDR (0.66) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2435267 | 0.82 | CDK2 (0.58) | KDRFLT1FLT4BRAFRET | |
| SCHEMBL2434299 | 0.81 | SRC (0.51) | KDRFLT1FLT4BRAFRET | |
| SCHEMBL2435963 | 0.77 | KDR (1.00) | KDRFLT1FLT4BRAFRET | |
| SCHEMBL8773800 | 0.76 | KDR (0.48) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL7781852 | 0.76 | KDR (0.48) | KDRFLT1FLT4KCNH2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |