Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.76 |
| ▸ | FLT1 | P17948 | 5/20 | 0.76 |
| ▸ | FLT4 | P35916 | 5/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431407 | 0.90 | KDR (0.62) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2436698 | 0.88 | KDR (0.78) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2431862 | 0.87 | KDR (0.59) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2435963 | 0.86 | KDR (1.00) | KDRFLT1FLT4BRAFMAPK14 | |
| SCHEMBL2431354 | 0.85 | KDR (0.65) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2437183 | 0.85 | KDR (0.78) | KDRFLT1FLT4BRAFMAPK14 | |
| SCHEMBL2437106 | 0.80 | KDR (0.72) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2441034 | 0.78 | KDR (0.68) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL5133392 | 0.76 | KDR (0.48) | KDRFLT1FLT4BRAFMAPK14 | |
| SCHEMBL274763 | 0.76 | KDR (1.00) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |