Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.59 |
| ▸ | FLT1 | P17948 | 2/20 | 0.59 |
| ▸ | FLT4 | P35916 | 2/20 | 0.59 |
| ▸ | BRAF | P15056 | 3/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431407 | 0.88 | KDR (0.62) | KDRFLT1FLT4BRAFPDGFRB | |
| SCHEMBL2434355 | 0.87 | KDR (0.76) | KDRFLT1FLT4BRAFPDGFRB | |
| SCHEMBL2439482 | 0.86 | KDR (0.67) | KDRFLT1FLT4BRAFPDGFRB | |
| SCHEMBL2435174 | 0.84 | HCK (0.56) | KDRFLT1FLT4BRAFCSF1R | |
| SCHEMBL2434445 | 0.82 | HCK (0.54) | KDRFLT1FLT4BRAFCSF1R | |
| SCHEMBL2436698 | 0.82 | KDR (0.78) | KDRFLT1FLT4BRAFPDGFRB | |
| SCHEMBL2431354 | 0.80 | KDR (0.65) | KDRFLT1FLT4BRAFPDGFRB | |
| SCHEMBL3308437 | 0.79 | KDR (0.46) | KDRBRAFCSF1RPDGFRBKIT | |
| SCHEMBL2434003 | 0.77 | HCK (0.55) | KDRFLT1FLT4BRAFCSF1R | |
| SCHEMBL2432172 | 0.77 | KDR (0.63) | KDRFLT1FLT4BRAFCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |