Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.78 |
| ▸ | FLT1 | P17948 | 4/20 | 0.78 |
| ▸ | FLT4 | P35916 | 4/20 | 0.78 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.59 |
| ▸ | CDK8 | P49336 | 3/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431354 | 0.91 | KDR (0.65) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL274763 | 0.88 | KDR (1.00) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2434355 | 0.88 | KDR (0.76) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1324005 | 0.86 | KDR (0.69) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2431407 | 0.85 | KDR (0.62) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL12024575 | 0.85 | KDR (0.80) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1324954 | 0.83 | KDR (0.73) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL1324123 | 0.83 | KDR (0.73) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2431862 | 0.82 | KDR (0.59) | KDRFLT1FLT4PDGFRBKIT | |
| SCHEMBL2435814 | 0.80 | KDR (0.87) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |