Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.59 |
| ▸ | FLT1 | P17948 | 3/20 | 0.59 |
| ▸ | FLT4 | P35916 | 3/20 | 0.59 |
| ▸ | CDK8 | P49336 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434130 | 0.89 | KDR (0.45) | KDRFLT1FLT4CDK8BRAF | |
| SCHEMBL2435966 | 0.86 | KDR (0.57) | KDRFLT1FLT4CDK8BRAF | |
| SCHEMBL2433250 | 0.86 | KDR (0.60) | KDRFLT1FLT4CDK8CDK1 | |
| SCHEMBL273466 | 0.83 | KDR (0.54) | KDRFLT1FLT4CDK8CDK2 | |
| SCHEMBL2434309 | 0.83 | KDR (0.50) | KDRFLT1FLT4BRAFKCNH2 | |
| SCHEMBL2435014 | 0.83 | KDR (0.52) | KDRFLT1FLT4CDK8CDK1 | |
| SCHEMBL12972322 | 0.83 | KDR (0.58) | KDRFLT1FLT4CDK8CDK1 | |
| SCHEMBL274235 | 0.80 | KDR (0.51) | KDRFLT1FLT4CDK8CDK2 | |
| SCHEMBL2436643 | 0.79 | CDK8 (0.61) | KDRFLT1FLT4CDK8CDK1 | |
| SCHEMBL2707860 | 0.78 | KDR (0.43) | KDRFLT1FLT4CDK8CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |