Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 4/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435966 | 0.91 | KDR (0.57) | KDRKCNH2BRAFFLT1FLT4 | |
| SCHEMBL2434130 | 0.87 | KDR (0.45) | KDRKCNH2BRAFFLT1FLT4 | |
| SCHEMBL2434322 | 0.85 | KDR (0.51) | KDRBRAFFLT1FLT4 | |
| SCHEMBL2434370 | 0.83 | KDR (0.59) | KDRKCNH2BRAFFLT1FLT4 | |
| SCHEMBL2432193 | 0.83 | KDR (0.56) | KDRKCNH2BRAFFLT1FLT4 | |
| SCHEMBL273466 | 0.80 | KDR (0.54) | KDRBRAFFLT1FLT4RAF1 | |
| SCHEMBL2437298 | 0.79 | AR (0.41) | KDRBRAF | |
| SCHEMBL2437389 | 0.78 | GRM4 (0.41) | — | |
| SCHEMBL2707647 | 0.77 | KMO (0.43) | KDR | |
| SCHEMBL274235 | 0.77 | KDR (0.51) | KDRBRAFFLT1FLT4RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |