Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 3/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17808838 | 0.84 | FYN (0.45) | GRM2RETCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL24345099 | 0.82 | RET (0.40) | GRM2RETCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL24344175 | 0.77 | CCNE1 (0.35) | RETCLK4KDRFYNBTK | |
| SCHEMBL24344137 | 0.76 | CHEK1 (0.34) | RETCLK4KDRFYNPDE4B | |
| SCHEMBL24345095 | 0.76 | CHEK1 (0.34) | RETCLK4KDRFYNPDE4B | |
| SCHEMBL24345092 | 0.70 | ALDH1A1 (0.41) | TSHRHSD17B10MAPTPDE4B | |
| SCHEMBL17808773 | 0.70 | GAPDH (0.47) | RETCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL24344150 | 0.70 | ALDH1A1 (0.41) | — | |
| SCHEMBL17802288 | 0.65 | CDK9 (0.47) | RETCLK4KDRFYNBTK | |
| SCHEMBL6048484 | 0.63 | GABRA1 (0.49) | GRM2CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227292-B1 | 4H-PYRIDO[1,2-a]PYRIMIDIN-4-ONE COMPOUNDS | ALTERITY THERAPEUTICS LTD (AU) | 2022-03-09 | — | — | EP | disclosed |