Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15288219 | 0.94 | AXL (0.49) | AXLTRPA1TRPM8TLR8MKNK1 | |
| SCHEMBL20517030 | 0.82 | TRPA1 (0.40) | AXLTRPA1TRPM8CHEK1RAB9A | |
| SCHEMBL29981187 | 0.80 | TRPA1 (0.41) | AXLTRPA1TRPM8MKNK1CHEK1 | |
| SCHEMBL25278627 | 0.80 | TRPA1 (0.41) | AXLTRPA1TRPM8MKNK1CHEK1 | |
| SCHEMBL15288252 | 0.78 | TRPA1 (0.39) | AXLTRPA1TRPM8CHEK1MAOB | |
| SCHEMBL20899454 | 0.77 | NOS1 (0.39) | AXLTRPA1TRPM8CHEK1MAOB | |
| SCHEMBL23982931 | 0.77 | TRPA1 (0.38) | AXLTRPA1TRPM8MKNK1CHEK1 | |
| SCHEMBL13872636 | 0.77 | EGFR (0.42) | EGFR | |
| SCHEMBL3560175 | 0.75 | AXL (0.73) | AXLTRPA1TRPM8TLR8MKNK1 | |
| SCHEMBL21190463 | 0.73 | LPL (0.46) | TLR8EGFRKDM4ESMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076975-A1 | 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |