Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26364368 | 0.95 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2SCN4AAKR1B1 | |
| SCHEMBL19954923 | 0.76 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2SCN4AAKR1B1 | |
| SCHEMBL19966718 | 0.74 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2SCN4AAKR1B1 | |
| SCHEMBL24420726 | 0.74 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2SCN4AAKR1B1 | |
| SCHEMBL19966707 | 0.74 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2SCN4AAKR1B1 | |
| SCHEMBL19308856 | 0.73 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2SCN4AAKR1B1 | |
| SCHEMBL26339590 | 0.72 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2SCN4AAKR1B1 | |
| SCHEMBL20098045 | 0.70 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2SCN4AAKR1B1 | |
| SCHEMBL18898373 | 0.70 | HDAC6 (0.37) | NPC1RAB9ASMN1; SMN2SCN4AAKR1B1 | |
| SCHEMBL20883882 | 0.69 | HDAC6 (0.36) | NPC1RAB9ASMN1; SMN2SCN4AAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076975-A1 | 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |