Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PDE2A | O00408 | 5/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12440619 | 0.77 | KIF11 (0.49) | ALDH1A1PDE2AKIF11TDP2CYP11B2 | |
| SCHEMBL20356287 | 0.77 | HTR2A (0.41) | ALDH1A1DHFRSLC2A1 | |
| SCHEMBL21304004 | 0.72 | ALDH1A1 (0.55) | ALDH1A1PDE2AKIF11P2RX3PKM | |
| SCHEMBL15723852 | 0.71 | CDC7 (0.43) | ALDH1A1PDE2AKIF11S1PR1CYP11B2 | |
| SCHEMBL1885008 | 0.71 | KMT2A (0.42) | ALDH1A1DHFRSLC2A1 | |
| SCHEMBL20097037 | 0.70 | KIF11 (0.51) | ALDH1A1PDE2AKIF11P2RX3MAT2A | |
| SCHEMBL21311348 | 0.69 | ALDH1A1 (0.46) | ALDH1A1PDE2AKIF11 | |
| SCHEMBL20097052 | 0.69 | KIF11 (0.64) | ALDH1A1PDE2AKIF11MAT2A | |
| SCHEMBL29342958 | 0.69 | SLC22A12 (0.46) | ALDH1A1 | |
| SCHEMBL20655579 | 0.68 | ALDH1A1 (0.44) | ALDH1A1PDE2AKIF11CYP11B2MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220112214-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2022-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112214-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, FRK | ALDH1A1 3607/4885PDE2A 2547/4885KIF11 2207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.