SCHEMBL24348331

SCHEMBL24348331

CC(=N)/C=C(\O)c1cnc(N2CCC(C(N)=O)CC2)nc1-c1ccc(C)o1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN11 Q06124 2/20 0.37
KMT2A Q03164 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
HDAC3 O15379 2/20 0.34
DNMT1 P26358 2/20 0.34
HDAC1 Q13547 2/20 0.34
HDAC2 Q92769 2/20 0.34
HDAC6 Q9UBN7 2/20 0.34
NCOR2 Q9Y618 2/20 0.34
ADORA2A P29274 2/20 0.34
ADORA3 P0DMS8 1/20 0.34
ADORA2B P29275 1/20 0.34
ADORA1 P30542 1/20 0.34
KDM4E B2RXH2 3/20 0.34
ALDH1A1 P00352 3/20 0.34
PKM P14618 2/20 0.34
ALOX12 P18054 1/20 0.34
CYP2C19 P33261 1/20 0.34
MAPT P10636 2/20 0.34
HTT P42858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24348336 0.78 HSD11B1 (0.37) PTPN11TDP1HDAC6KDM4EALDH1A1
SCHEMBL26550783 0.75 PRKAB2 (0.55) KMT2ATDP1KDM4EALDH1A1PKM
SCHEMBL2555821 0.64 CYP3A4 (0.51) KMT2ATDP1HDAC6KDM4EALDH1A1
SCHEMBL24348939 0.62 PTPN11 (0.40) PTPN11KMT2ATDP1KDM4EALDH1A1
SCHEMBL14658203 0.62 CAMK1D (0.59) CYP2C19
SCHEMBL12085360 0.61 CAMK1D (0.57) CYP2C19
SCHEMBL20533493 0.61 CYP3A4 (0.53) KMT2AHDAC6KDM4EALDH1A1PKM
SCHEMBL2560189 0.60 SMN1; SMN2 (0.58) TDP1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL12288871 0.60 HDAC6 (0.52) KMT2AHDAC6KDM4EALDH1A1CYP2C19
SCHEMBL15740759 0.60 KDM4E (0.49) KDM4EALDH1A1CYP2C19SMN1; SMN2EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022053803-A1 HERBICIDAL PYRIMIDINE DERIVATIVES MOA Technology Limited (GB) 2022-03-17 WO disclosed