SCHEMBL24348336

SCHEMBL24348336

CC(=N)/C=C(\O)c1cnc(N2CCC(C(N)=O)CC2)nc1C(C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.37
KDM4E B2RXH2 3/20 0.36
PTPN11 Q06124 2/20 0.36
ABL1 P00519 1/20 0.36
LMNA P02545 1/20 0.36
CYP3A4 P08684 1/20 0.36
POLB P06746 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TDP1 Q9NUW8 2/20 0.35
ALDH1A1 P00352 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
EGFR P00533 1/20 0.35
CAMK1D Q8IU85 3/20 0.34
USP2 O75604 1/20 0.34
HPGD P15428 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
HSD17B10 Q99714 1/20 0.34
BTK Q06187 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24348357 0.81 MAPT (0.37) HSD11B1KDM4EPTPN11LMNACYP3A4
SCHEMBL24348331 0.78 PTPN11 (0.37) KDM4EPTPN11POLBSMN1; SMN2TDP1
SCHEMBL26550804 0.69 TMEM97 (0.39) KDM4ETDP1ALDH1A1USP2HPGD
SCHEMBL12071831 0.66 HDAC6 (0.49) KDM4EABL1LMNACYP3A4SMN1; SMN2
SCHEMBL2555821 0.66 CYP3A4 (0.51) KDM4EABL1LMNACYP3A4POLB
SCHEMBL1015076 0.66 HSD11B1 (0.57) HSD11B1KDM4EPTPN11POLBSMN1; SMN2
SCHEMBL20533493 0.65 CYP3A4 (0.53) KDM4EABL1LMNACYP3A4POLB
SCHEMBL12288871 0.64 HDAC6 (0.52) KDM4EABL1LMNACYP3A4SMN1; SMN2
SCHEMBL14658203 0.64 CAMK1D (0.59) CAMK1DBTK
SCHEMBL12085360 0.63 CAMK1D (0.57) CAMK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022053803-A1 HERBICIDAL PYRIMIDINE DERIVATIVES MOA Technology Limited (GB) 2022-03-17 WO disclosed