SCHEMBL24348342

SCHEMBL24348342

CC(=N)/C=C(\O)c1cnc(NCc2cccnc2)nc1C(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 1/20 0.44
FGFR1 P11362 1/20 0.44
KDR P35968 1/20 0.44
VNN1 O95497 6/20 0.42
HDAC3 O15379 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
LTA4H P09960 1/20 0.40
CDK2 P24941 4/20 0.39
CDK9 P50750 3/20 0.39
USP1 O94782 1/20 0.39
WDR48 Q8TAF3 1/20 0.39
GPR84 Q9NQS5 1/20 0.38
CCNT1 O60563 2/20 0.38
CDK1 P06493 2/20 0.38
CDK4 P11802 2/20 0.38
CCNB1 P14635 2/20 0.38
CCND1 P24385 2/20 0.38
CCNE1 P24864 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24349004 0.82 HDAC3 (0.40) IGF1RFGFR1KDRVNN1HDAC3
SCHEMBL24348352 0.75 MAPK3 (0.31)
SCHEMBL24348344 0.73 LMNA (0.47) IGF1RCDK2CDK9CCNT1CCNA2
SCHEMBL24349480 0.70 CDK4 (0.43) HDAC3HDAC1HDAC2HDAC6CDK2
SCHEMBL24349015 0.68 VNN1 (0.37) VNN1JAK3
SCHEMBL24349479 0.68 MAPK1 (0.43) HDAC3HDAC1HDAC2HDAC6MAPK1
SCHEMBL24348474 0.67 CNR2 (0.49) CDK2CCNE1JAK2JAK3
SCHEMBL24349469 0.67 TDP1 (0.37)
SCHEMBL26550813 0.67 POLB (0.47) IGF1RFGFR1KDRVNN1HDAC1
SCHEMBL24349486 0.66 ACACB (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022053803-A1 HERBICIDAL PYRIMIDINE DERIVATIVES MOA Technology Limited (GB) 2022-03-17 WO disclosed