Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.56 |
| ▸ | DHFR | P00374 | 4/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388414 | 0.84 | FGFR1 (0.75) | FGFR1DHFRFGFR2FGFR4FGFR3 | |
| SCHEMBL28809367 | 0.77 | DHFR (0.58) | FGFR1DHFRFGFR3ADORA1FYN | |
| SCHEMBL2435150 | 0.75 | PIK3CA (0.51) | DHFR | |
| SCHEMBL30488034 | 0.73 | ADORA2A (0.72) | FGFR1DHFRADORA2AADORA1FYN | |
| SCHEMBL4457331 | 0.73 | ADORA2A (0.72) | FGFR1DHFRADORA2AADORA1FYN | |
| SCHEMBL5619571 | 0.72 | FGFR1 (1.00) | FGFR1DHFRFGFR2FGFR4FGFR3 | |
| SCHEMBL264291 | 0.72 | KMT2A (0.73) | FGFR1DHFRKMT2ATP53MAPT | |
| SCHEMBL30488020 | 0.72 | KMT2A (0.73) | FGFR1DHFRKMT2ATP53MAPT | |
| SCHEMBL2437579 | 0.70 | DHFR (0.67) | FGFR1DHFRKMT2AFYNTSHR | |
| SCHEMBL2437487 | 0.69 | HTR6 (0.50) | EGFRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552211-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011120025-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |