SCHEMBL24352012

SCHEMBL24352012

Cc1cc2c(cc1-c1ccc(Br)cc1)C(C)(C)c1cc(-c3ccc(Br)cc3)c(C)cc1-2

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RXRA P19793 2/20 0.40
RXRB P28702 1/20 0.40
RXRG P48443 1/20 0.40
ALDH1A1 P00352 3/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
TSHR P16473 2/20 0.33
CYP3A4 P08684 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
MAOB P27338 2/20 0.33
MAOA P21397 1/20 0.33
TDP2 O95551 1/20 0.33
MAPK1 P28482 1/20 0.31
DHFR P00374 1/20 0.31
RAPGEF4 Q8WZA2 1/20 0.31
ALK Q9UM73 1/20 0.31
RARB P10826 1/20 0.31
RARG P13631 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24352183 0.95 ALDH1A1 (0.43) RXRARXRBRXRGALDH1A1NPC1
SCHEMBL13779987 0.84 ALDH1A1 (0.46) ALDH1A1NPC1RAB9ASMN1; SMN2TSHR
SCHEMBL545981 0.78 ALKBH3 (0.38) RXRARXRBRXRGALDH1A1NPC1
SCHEMBL12148725 0.78 ALDH1A1 (0.43) ALDH1A1NPC1RAB9ASMN1; SMN2TSHR
SCHEMBL10025100 0.77 ABL1 (0.42) RXRARXRBRXRGALDH1A1NPC1
SCHEMBL21370682 0.76 PDK2 (0.39) RXRARXRBRXRGALDH1A1NPC1
SCHEMBL24352015 0.75 ALDH1A1 (0.39) RXRARXRBRXRGALDH1A1CYP3A4
SCHEMBL24352192 0.75 ALDH1A1 (0.39) RXRARXRBRXRGALDH1A1CYP3A4
SCHEMBL824234 0.75 TDP2 (0.42) ALDH1A1NPC1RAB9ASMN1; SMN2TDP2
SCHEMBL14271354 0.75 NPC1 (0.39) ALDH1A1NPC1RAB9ASMN1; SMN2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022059725-A1 POLYMER 三菱ケミカル株式会社 2022-03-24 WO disclosed