SCHEMBL24352183

SCHEMBL24352183

Cc1ccc(-c2cc3c(cc2C)-c2cc(C)c(-c4ccc(Br)cc4)cc2C3(C)C)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
RXRA P19793 1/20 0.38
RXRB P28702 1/20 0.38
RXRG P48443 1/20 0.38
MAOB P27338 2/20 0.34
MAPT P10636 4/20 0.33
KDM4E B2RXH2 2/20 0.33
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
CYP3A4 P08684 2/20 0.32
HTT P42858 2/20 0.32
RAPGEF4 Q8WZA2 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C19 P33261 1/20 0.32
NPC1 O15118 6/20 0.32
RAB9A P51151 5/20 0.32
APP P05067 1/20 0.31
PAX8 Q06710 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24352012 0.95 RXRA (0.40) ALDH1A1RXRARXRBRXRGMAOB
SCHEMBL13779987 0.80 ALDH1A1 (0.46) ALDH1A1MAOBMAPTLMNAMEN1
SCHEMBL545981 0.77 ALKBH3 (0.38) ALDH1A1RXRARXRBRXRGMAOB
SCHEMBL23908222 0.75 TDP1 (0.47) ALDH1A1MAOBMAPTKDM4ELMNA
SCHEMBL13911507 0.75 PDK2 (0.44) ALDH1A1MAPTKDM4ELMNAHPGD
SCHEMBL22884256 0.75 PDK2 (0.41) ALDH1A1MAOBMAPTKDM4ELMNA
SCHEMBL18615369 0.74 ALDH1A1 (0.38) ALDH1A1MAPTLMNAMEN1KMT2A
SCHEMBL12439574 0.74 ALDH1A1 (0.38) ALDH1A1MAPTLMNAMEN1KMT2A
SCHEMBL12148725 0.73 ALDH1A1 (0.43) ALDH1A1MAOBMAPTKDM4ELMNA
SCHEMBL10025100 0.73 ABL1 (0.42) ALDH1A1RXRARXRBRXRGMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022059725-A1 POLYMER 三菱ケミカル株式会社 2022-03-24 WO disclosed