Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20993629 | 1.00 | HTR3A (0.41) | HTR3AHRH4SLC6A4CYP2D6SLC6A2 | |
| SCHEMBL20993537 | 1.00 | HTR3A (0.41) | HTR3AHRH4SLC6A4CYP2D6SLC6A2 | |
| SCHEMBL12807031 | 0.76 | SLC6A2 (0.49) | HTR3ASLC6A4CYP2D6SLC6A2SLC6A3 | |
| SCHEMBL27911852 | 0.74 | HTT (0.47) | HRH4HTR2CHTR2AHTR2BKDM4E | |
| SCHEMBL16053272 | 0.73 | HTR3A (0.41) | HTR3ASLC6A4CYP2D6SLC6A2SLC6A3 | |
| SCHEMBL6110760 | 0.73 | HTR2C (0.38) | SLC6A4CYP2D6SLC6A2SLC6A3HTR2C | |
| SCHEMBL10623387 | 0.71 | SLC6A2 (0.47) | HTR3AHRH4SLC6A4CYP2D6SLC6A2 | |
| SCHEMBL31232802 | 0.71 | PLD1 (0.42) | HTR2CHTR2AHTR2BALDH1A1HTR1A | |
| SCHEMBL2900748 | 0.71 | PLD1 (0.42) | HTR2CHTR2AHTR2BKDM4EALDH1A1 | |
| SCHEMBL9984343 | 0.71 | HTR2A (0.39) | SLC6A4CYP2D6SLC6A2SLC6A3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119400-A1 | QUINAZOLINE AND INDOLE COMPOUNDS TO TREAT MEDICAL DISORDERS | ACHILLION PHARMACEUTICALS INC (US) | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119400-A1 | QUINAZOLINE AND INDOLE COMPOUNDS TO TREAT MEDICAL DISORDERS | CFB, TFPI, MAOB | HTR3A 56/4885HRH4 69/4885SLC6A4 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.