Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.44 |
| ▸ | CDK1 | P06493 | 5/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.44 |
| ▸ | KIF11 | P52732 | 6/20 | 0.40 |
| ▸ | TDP2 | O95551 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834730 | 0.81 | GSK3B (0.42) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL6179151 | 0.73 | GSK3B (0.41) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL31734651 | 0.70 | TDP2 (0.54) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL3224720 | 0.69 | TDP2 (0.66) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL6179642 | 0.68 | CES1 (0.41) | TDP2MEN1KMT2A | |
| SCHEMBL5502802 | 0.67 | MAPT (0.43) | GSK3BCDK5CDK5R1KIF11TDP2 | |
| SCHEMBL496908 | 0.67 | CA9 (0.37) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL6218249 | 0.67 | KMT2A (0.33) | MEN1KMT2A | |
| SCHEMBL25424253 | 0.67 | TDP2 (0.58) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL10129810 | 0.67 | POLB (0.37) | GSK3BCDK5CDK5R1CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4234548-A1 | SUBSTITUTED BENZO OR PYRIDOPYRIMIDINE AMINE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Suzhou Zelgen Biopharmaceutical Co., Ltd. (CN) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022083657-A1 | SUBSTITUTED BENZO OR PYRIDOPYRIMIDINE AMINE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 苏州泽璟生物制药股份有限公司 | 2022-04-28 | — | — | WO | disclosed |