Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.42 |
| ▸ | CDK1 | P06493 | 6/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.42 |
| ▸ | TDP2 | O95551 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24355256 | 0.81 | GSK3B (0.44) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL5378136 | 0.78 | CA12 (0.40) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL25746058 | 0.75 | GSK3B (0.38) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL12992123 | 0.75 | GRIA1 (0.41) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL10129810 | 0.75 | POLB (0.37) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL31734651 | 0.71 | TDP2 (0.54) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL3224720 | 0.70 | TDP2 (0.66) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL18210207 | 0.70 | SRC (0.47) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL10714014 | 0.70 | GRIA1 (0.49) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL29521546 | 0.68 | PARP10 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4791129-A | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4725616-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0208510-A2 | 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | PFIZER INC. (US) | 1987-01-14 | — | — | EP | disclosed |