Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29516062 | 0.86 | HDAC3 (0.54) | LMNAALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL15480445 | 0.83 | ALDH1A1 (0.67) | LMNAALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL15480447 | 0.83 | ALDH1A1 (0.67) | LMNAALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL15480450 | 0.83 | ALDH1A1 (0.67) | LMNAALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL15480448 | 0.83 | ALDH1A1 (0.67) | LMNAALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL15480444 | 0.81 | ALDH1A1 (0.68) | LMNAALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL7142997 | 0.79 | ADORA2A (0.64) | LMNAALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL30444389 | 0.79 | LMNA (0.60) | LMNAALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL17817590 | 0.79 | ADORA2A (0.64) | LMNAALDH1A1HPGDNPSR1HSD17B10 | |
| SCHEMBL7934381 | 0.77 | ALDH1A1 (0.64) | LMNAALDH1A1HPGDNPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240327427-A1 | NEW COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2024-10-03 | — | — | US | disclosed |
| WO-2022087456-A1 | NEW COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |
| WO-2022087456-A1 | NEW COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240327427-A1 | NEW COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | PSEN2, PSEN1, CHAT | LMNA 3057/4885ALDH1A1 1841/4885HPGD 1043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.