Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | SCN1A | P35498 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.54 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | MIF | P14174 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3067381 | 0.90 | HRH3 (0.54) | HRH3ALDH1A1MAPK1SIGMAR1CYP1A2 | |
| SCHEMBL30979868 | 0.90 | HRH3 (0.54) | HRH3ALDH1A1MAPK1SIGMAR1CYP1A2 | |
| SCHEMBL28032396 | 0.86 | HRH3 (0.62) | HRH3ALDH1A1SIGMAR1USP2SRC | |
| SCHEMBL30209182 | 0.85 | HRH3 (0.49) | HRH3HRH2HRH1EGFR | |
| SCHEMBL6386440 | 0.84 | KDM4E (0.55) | ALDH1A1CYP1A2FGFR1SRCKDM4E | |
| SCHEMBL28126949 | 0.82 | LTA4H (0.53) | HRH3KDM4EEGFR | |
| SCHEMBL2502393 | 0.80 | ALDH1A1 (0.54) | HRH3ALDH1A1MAPK1SIGMAR1CYP1A2 | |
| SCHEMBL7837580 | 0.79 | HRH3 (0.53) | HRH3KCNH2EGFR | |
| SCHEMBL18024049 | 0.78 | MIF (0.56) | HRH3ALDH1A1MAPK1SIGMAR1CYP1A2 | |
| SCHEMBL29427198 | 0.78 | AURKA (0.56) | HRH3KCNH2FGFR1SRCKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103923023-B | The novel method of a kind of Gefitinib and derivative Microwave synthesize thereof | FUJIAN MEDICAL UNIVERSITY (CN) | 2016-03-30 | — | — | CN | claimed |
| CN-105153065-A | Preparation method of 4-(3-chloro-4-fluorophenyl amido)-7-methoxy-6-(3-morpholine propoxy) quinazoline | SHANGHAI TIANCI INTERNAT PHARMACEUTICAL CO LTD | 2015-12-16 | — | — | CN | claimed |
| EP-1546119-A1 | PROCESS FOR THE PREPARATION OF 4- (3'CHLORO-4'-FLUOROANILINO) -7-METHOXY-6- (3-MORPHOLINOPROPOXY) QUINAZOLINE | AstraZeneca AB (SE) | 2005-06-29 | — | — | EP | claimed |
| WO-2004024703-A1 | PROCESS FOR THE PREPARATION OF 4- (3’-CHLORO-4’-FLUOROANILINO) -7-METHOXY-6- (3-MORPHOLINOPROPOXY) QUINAZOLINE | ASTRAZENECA AB (SE) | 2004-03-25 | — | — | WO | claimed |
| CN-103923023-B | The novel method of a kind of Gefitinib and derivative Microwave synthesize thereof | FUJIAN MEDICAL UNIVERSITY (CN) | 2016-03-30 | — | — | CN | disclosed |
| CN-103923023-B | The novel method of a kind of Gefitinib and derivative Microwave synthesize thereof | FUJIAN MEDICAL UNIVERSITY (CN) | 2016-03-30 | — | — | CN | disclosed |
| CN-105153065-A | Preparation method of 4-(3-chloro-4-fluorophenyl amido)-7-methoxy-6-(3-morpholine propoxy) quinazoline | SHANGHAI TIANCI INTERNAT PHARMACEUTICAL CO LTD | 2015-12-16 | — | — | CN | disclosed |
| WO-2011112588-A2 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS | CASE WESTERN RESERVE UNIVERSITY (US) | 2011-09-15 | — | — | WO | disclosed |
| CN-101348471-A | Process for the preparation of 4- (3'chloro-4'-fluoroanilino) -7-methoxy-6- (3-morpholinopropoxy) quinazoline | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | CN | disclosed |
| CN-1652790-A | Crystalline forms of the anti-cancer compound ZD1839 | ASTRAZENECA AB (SE) | 2005-08-10 | — | — | CN | disclosed |
| EP-1480650-A1 | NOVEL CRYSTALLINE FORMS OF THE ANTI-CANCER COMPOUND ZD1839 | AstraZeneca AB (SE) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003072108-A1 | NOVEL CRYSTALLINE FORMS OF THE ANTI-CANCER COMPOUND ZD1839 | ASTRAZENECA AB (SE) | 2003-09-04 | — | — | WO | disclosed |