Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5680969 | 0.99 | HRH3 (0.55) | HRH3KCNH2TLR9TLR7ACHE | |
| SCHEMBL6390332 | 0.92 | MAOB (0.52) | HRH3EGFRKCNH2 | |
| SCHEMBL28032867 | 0.90 | HRH3 (0.62) | HRH3EGFR | |
| SCHEMBL30979868 | 0.89 | HRH3 (0.54) | HRH3EGFRKCNH2 | |
| SCHEMBL30209183 | 0.89 | HRH3 (0.49) | HRH3EGFR | |
| SCHEMBL3067381 | 0.89 | HRH3 (0.54) | HRH3EGFRKCNH2 | |
| SCHEMBL5679317 | 0.86 | HRH3 (0.45) | HRH3EGFRTLR9 | |
| SCHEMBL6689692 | 0.86 | HRH3 (0.45) | HRH3EGFRTLR9TLR7 | |
| SCHEMBL18128966 | 0.83 | EGFR (0.54) | HRH3EGFR | |
| SCHEMBL28126949 | 0.83 | LTA4H (0.53) | HRH3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |