Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18753542 | 0.76 | HPGD (0.37) | HPGDKDM4EHSD17B10CHRNB2CHRNB4 | |
| SCHEMBL2540307 | 0.71 | — | — | |
| SCHEMBL7457229 | 0.64 | NAAA (0.47) | POLBEPHX1 | |
| SCHEMBL13728780 | 0.64 | BCHE (0.41) | HPGDKDM4EHSD17B10CHRNB2CHRNB4 | |
| SCHEMBL6360425 | 0.60 | CHRNB2 (0.46) | HPGDKDM4EHSD17B10CHRNB2CHRNB4 | |
| SCHEMBL103494 | 0.60 | — | — | |
| SCHEMBL10154125 | 0.60 | CHRNB2 (0.42) | HPGDKDM4EHSD17B10CHRNB2CHRNB4 | |
| SCHEMBL17923869 | 0.59 | CHRNB2 (0.53) | HPGDKDM4EHSD17B10CHRNB2CHRNB4 | |
| SCHEMBL20868252 | 0.59 | CHRNB2 (0.53) | HPGDKDM4EHSD17B10CHRNB2CHRNB4 | |
| SCHEMBL2540554 | 0.59 | CHRNB2 (0.53) | HPGDKDM4EHSD17B10CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218375-B1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH INC (US) | 2022-04-27 | — | — | EP | disclosed |